Jef Van den Ende

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Despite extensive analysis of the BRCA1 and BRCA2 genes, germline mutations are detected in <20% of families with a presumed genetic predisposition for breast and ovarian cancer. Recent literature reported RAD51C as a new breast cancer susceptibility gene. In this study, we report the analysis of 410 patients from 351 unrelated pedigrees. All were referred(More)
The concept of likelihood ratio has been advocated for several years as one of the better means to evaluate diagnostic tests and as a practical and valuable tool in clinical decision making. In this paper we review the basic concepts underlying the evaluation of diagnostic tests and we explore the properties and usefulness of both positive and negative(More)
Five to 10 % of all breast cancer cases are due to mutations of high penetrance susceptibility genes, especially BRCA1 and BRCA2. In families with known BRCA mutations, disclosure of genetic test results could induce relatives to undergo genetic testing themselves and adopt cancer risk management strategies, if necessary. This study examines disclosure(More)
In a study with 75 greenhouse soils, the ionic concentrations in soil solutions were compared with those in saturation extracts and in specific 1:2 by volume extracts. The soils involved represented a wide variety of soil types. The EC and all major ions were involved in the investigation. Useful estimates of ionic concentrations in soil solutions could be(More)
The prozone effect (or high doses-hook phenomenon) consists of false-negative or false-low results in immunological tests, due to an excess of either antigens or antibodies. Although frequently cited as a cause of false-negative results in malaria rapid diagnostic tests (RDTs), especially at high parasite densities of Plasmodium falciparum, it has been(More)
BACKGROUND To estimate the amount of regret and weights of harm by omission and commission during therapeutic decisions for smear-negative pulmonary Tuberculosis. METHODS An interviewer-administered survey was done among young physicians in India, Pakistan and Bangladesh with a previously used questionnaire. The physicians were asked to estimate(More)
A greenhouse screening method for resistance to ringspot (Mycosphaerella brassicicola) inBrassica oleracea is described. High infection levels were achieved by spraying young plants by mycelial inoculum enriched with 3% sucrose. The screening method was tested on three Brussels sprouts, three cabbage and three cauliflower cultivars, with known reactions to(More)
Tobacco rattle tobravirus (TRV) may infect several ornamental bulb crops and is transmitted by trichodorid nematodes. Paratrichodorus teres, P. pachydermus and Trichodorus similis are the main vectors in the Netherlands. In field experiments the effects of various pre-crops and organic amendments on the TRV Infection Potential of Soils (TRV-IPS) and on(More)
Isolates ofMycosphaerella brassicicola, originating from various locations in Europe, differed in their virulence on a differential set of brassica cultivars, as measured by the number of lesions per leaf. Hypersensitivity and significant cultivar-isolate effects were observed, indicating a differential host-pathogen interaction. Although expression of(More)