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Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood. Recent studies of dosage compensation,… Expand
Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
A systematic computational method predicts new uses for existing drugs by integrating public gene expression signatures of drugs and diseases. Greening Drug Discovery Recycling is good for the… Expand
N6-Methyladenosine Modification Controls Circular RNA Immunity.
Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self versus foreign… Expand
Boosting Cancer Immunotherapy with Anti-CD137 Antibody Therapy
- A. Yonezawa, Suparna Dutt, C. Chester, Jeewon Kim, H. Kohrt
- Clinical Cancer Research
- 23 April 2015
In the past 5 years, immunomodulatory antibodies have revolutionized cancer immunotherapy. CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for… Expand
Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model
- Jeewon Kim, S. Thorne, Lihan Sun, Baocheng Huang, D. Mochly-Rosen
- Biology, Medicine
- 20 September 2010
Metastasis is the major reason for breast cancer-related deaths. Although there is a host of indirect evidence for a role of protein kinase C (PKC) α in primary breast cancer growth, its role in the… Expand
Discovery of a Novel Class of Covalent Inhibitor for Aldehyde Dehydrogenases*
- M. Khanna, C. Chen, +8 authors T. Hurley
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 21 October 2011
Background: ALDH enzymes metabolize aldehydes in many pathways, including the inactivation of cyclophosphamide. Results: Covalent inhibitors against ALDH were discovered, and their mechanism of… Expand
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.
Angiogenesis is critical in the progression of prostate cancer. However, the interplay between the proliferation kinetics of tumor endothelial cells (angiogenesis) and tumor cells has not been… Expand
Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor.
Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs), particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family of enzymes detoxify both exogenous… Expand
Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Lesnik et al., 2016) that described how we intended to replicate selected experiments from the paper ‘Melanoma… Expand
PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC‐3 prostate cancer cells
PKCδ is generally known as a pro‐apoptotic and anti‐proliferative enzyme in human prostate cancer cells.