Jeet B Singh

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The role of glia in modulating neuronal network activity is an important question. Oligodendrocyte precursor cells (OPC) characteristically express the transmembrane proteoglycan nerve-glia antigen 2 (NG2) and are unique glial cells receiving synaptic input from neurons. The development of NG2+ OPC into myelinating oligodendrocytes has been well studied,(More)
Neuronal networks are balanced by mechanisms of homeostatic plasticity, which adjusts synaptic strength via molecular and morphological changes in the pre- and post-synapse. Here, we wondered whether the hyaluronic acid-based extracellular matrix (ECM) of the brain is involved in mechanisms of homeostatic plasticity. We hypothesized that the ECM, being rich(More)
The present study was designed to evaluate targeting efficiency of carboplatin anticancer drug. Drug was encapsulated in natural biodegradable polymer sodium alginate. The nanoparticles were prepared by the ion gelification technique and evaluated for encapsulation efficiency, loading capacity, in vitro release pattern and targeting efficiency. Drug(More)
IntroductionAssessment of maturational status is a decisive factor in deciding treatment modality. Various methods till date have been tested to define individual’s maturation. This study comprised of 60 samples divided in 3 groups. Group I normal grower (control), group II vertical growers and group III horizontal growers. Each sample was assessed for(More)
The authors would like to thank the Ford Foundation for its generosity. Without such funding, ISOFI would not have transformed the lives, organizations and programs as was observed over the past two years. Special thanks goes to Sarah Costa for having a vision and translating it into action. Thanks also for the insights of Susan Wood and Roshmi Goswami,(More)
A total o f 28 strains o f several species o f Rhizobium were screened for the presence and regulation of the enzyme alkaline phosphatase. In contrast to all other species o f Rhizobium, the activity of this enzyme was absent in R. trifolii. D ifferent levels o f alkaline phosphatase were observed in various species o f Rhizobium. Both, species as well as(More)
Protein phosphorylation is known to regulate synaptic plasticity and memory. Protein kinases including protein kinase A and extracellular signal-regulated kinase (ERK) play important roles in these processes. Forskolin, a protein kinase A activator, induces long-term potentiation (LTP) in the hippocampus. Forskolin also induces ERK activation, which plays(More)