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Alcohol dependence (AD) is a multifactorial and polygenic disorder involving complex gene-to-gene and gene-to-environment interactions. Several genome-wide association studies have reported numerous risk factors for AD, but replication results following these studies have been controversial. To identify new candidate genes, the present study used GWAS and(More)
Consumption of large amounts of alcohol is known to have negative effects, but consumption in smaller amounts may be protective. The effect of alcohol may be greater in the elderly than in younger adults, particularly with regard to cognition. However, the drinking pattern that will provide optimal protection against dementia and cognitive decline in the(More)
OBJECTIVES To identify regional alterations of white matter integrity associated with apathy in Alzheimer disease (AD). DESIGN Cross-sectional study. SETTING University Dementia Clinic. PARTICIPANTS Fifty-one very mild or mild probable AD subjects. INTERVENTION Volumetric magnetic resonance imaging with diffusion tensor imaging. MEASUREMENTS(More)
Diced cartilage grafting has re-emerged as a popular method in aesthetic rhinoplasty since the introduction of Erol's Turkish delight technique. However, an extensive literature review indicates that diced cartilage grafts with Surgicel(®) wrapping are usually absorbed and often fail to correct associated clinical problems. Recent studies show that(More)
OBJECTIVE To investigate the relationship between in vivo brain amyloid-beta (Aβ) burden, measured by C-labeled Pittsburgh Compound B (C-PiB) retention, and age-at-onset in patients with Alzheimer disease (AD). DESIGN Cross-sectional study. SETTING University Dementia Clinic. PARTICIPANTS Twenty-two AD patients including 11 early-onset AD (EOAD: onset(More)
OBJECTIVES This study aimed to validate the two total scores (TS-I and TS-II) of the Consortium to Establish a Registry for Alzheimer Disease neuropsychological battery (CERAD-NP) for a large elderly population including mild cognitive impairment (MCI) and dementia patients with various etiologic backgrounds. The authors also investigated whether the(More)
OBJECTIVE Depression is a very common symptom in people with mild cognitive impairment (MCI), a preclinical stage of Alzheimer's disease (AD), and in those with clinically evident AD. Moreover, MCI individuals with depression show a higher conversion rate to clinical AD than those without depression. This study aimed to elucidate the functional(More)
We investigated the case of a young man with blurred vision in his left eye. His visual acuity was slightly decreased, and ophthalmoscopy disclosed a gray-white lesion in the macula. He had no systemic or ocular history. On the visual field test, the threshold sensitivity was decreased in the corresponding region. Spectral domain optical coherence(More)
AIMS To identify an optimal brief version of the Alcohol Use Disorders Identification Test (AUDIT) and to evaluate its effectiveness as a screening test for problem drinking (PD), alcohol use disorders (AUD) and alcohol dependence (AD). METHODS A multicenter trial was conducted from March, 2010, to January, 2012, in 101 normal comparison, 203 risky(More)
We compared the predictive ability of the various neuroimaging tools and determined the most cost-effective, non-invasive Alzheimer's disease (AD) prediction model in mild cognitive impairment (MCI) individuals. Thirty-two MCI subjects were evaluated at baseline with [(18)F]-fluorodeoxyglucose positron emission tomography (FDG-PET), MRI, diffusion tensor(More)