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VEGFR inhibitors are in broad use for the treatment of metastatic renal-cell carcinoma, gastrointestinal stromal tumors and hepatocellular carcinoma and in development in a number of other oncology indications, including colorectal cancer, non-small-cell lung cancer, pancreatic cancer, thyroid malignancies, ovarian cancer, breast cancer and sarcomas. This(More)
Walking appears to be a simple innate ability, but it is an extraordinarily complex process involving three major afferent systems (visual, proprioception, and vestibular). Humans' unique gait is established around age seven. Velocity and step-length change with age, but the overall package we call "gait" remains stable. Age is the single most important(More)
After more than 50 years of experience with benzodiazepines, the American health care system has a love-hate relationship with them. In 1955, Hoffmann-La Roche chemist Leo Sternbach serendipitously identified the first benzodiazepine, chlordiazepoxide (Librium). By 1960, Hoffmann-La Roche marketed it as Librium, and it pursued molecular modifications for(More)
Numerous market factors have converged to create a need for change in the drug development process. Public scrutiny, high failure rates for investigational agents, and concern about the use of animals in research, are just a few. In response, some changes in this process are being made. Microdosing--administering very small, radiolabeled doses of(More)
Most pharmacists know that aspirin's origins lie with willow bark, but they may be unaware of its role in the development of the pharmaceutical industry. Evolving from salacin (the active ingredient in many plant remedies) to salicylic acid (an analgesic in its own right) to the more effective, less toxic acetylsalicylic acid, this pain reliever cornered(More)
One in five people with dementia wander. Long-term care facilities must deal with wandering while simultaneously protecting residents, complying with life-safety codes, maintaining a home-like environment, and respecting resident rights. Wanderers tend to be physically healthier than those who do not wander, but more behaviorally disturbed. Experts indicate(More)
Progressive muscle weakness and fasciculations can indicate developing amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease. Its treatment and prognosis have been unchanged for almost 100 years, although our understanding on a cellular level is better. All ALS patients can be expected to progress to a state that requires complete supportive(More)
External physical insult, an accidental blow, acceleration followed by rapid deceleration, or explosive blasts can cause traumatic brain injury (TBI). During the last few years, experts have realized that even mild blows to the head can cause lasting damage. Better understanding of how TBI occurs has improved the probability of survival for those with the(More)
For a variety of reasons, residents of long-term care facilities often lack basic dental care, leading to poor nutrition, needless pain, medical complications, and unnecessary tooth loss. The "Healthy People 2010" initiative included a goal to reduce the number of older adults who have had all their natural teeth extracted, and increase the proportion of(More)