Jeanne Oiticica

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We ascertained a Brazilian family with nine individuals affected by autosomal dominant nonsyndromic sensorineural hearing loss. The bilateral hearing loss affected mainly mid-high frequencies, was apparently stable with an early onset. Microsatellites close to the DFNA8/DFNA12 locus, which harbors the TECTA gene, showed significant multipoint lod scores(More)
Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss. Although guinea pigs have been widely used as an excellent experimental model for studying the biology of the inner ear, the mouse cochlea has been more suitable for yielding otospheres in vitro. The aim of this(More)
Introduction Tinnitus is an abnormal perception of sound in the absence of an external stimulus. Chronic tinnitus usually has a high impact in many aspects of patients' lives, such as emotional stress, sleep disturbance, concentration difficulties, and so on. These strong reactions are usually attributed to central nervous system involvement. Neuroimaging(More)
INTRODUCTION The public and private health care in the city of São Paulo has no data on tinnitus prevalence. OBJECTIVE Determine tinnitus prevalence in São Paulo city. STUDY DESIGN Series study. METHODS Cross-sectional study by field questionnaire with 1960 interviews. Predictor variables included gender, age, tinnitus. RESULTS The prevalence of(More)
In 20% of cases, hereditary non-syndromic hearing loss has an autosomal dominant inheritance (ADNSHL). To date, more than 50 loci for ADNSHL have been mapped to different chromosomal regions. In order to verify whether genomic alterations contribute to the hearing loss etiology and to search for novel deafness candidate loci, we investigated probands from(More)
OBJECTIVES The aim of the present study was to establish the frequency of metabolic disorders among patients with sudden deafness and to compare this frequency with data from population surveys. INTRODUCTION No consensus has been reached regarding the prevalence of metabolic disorders among sudden deafness patients or their influence as associated risk(More)
UNLABELLED The epidemiology of dizziness is essential in clinical practice. OBJECTIVE To establish the prevalence of dizziness in the adult population of São Paulo, its clinical characteristics and level of discomfort. METHOD A prospective cross-sectional study ran from April to October of 2012 by a field questionnaire, totaling 1,960 interviews. The(More)
INTRODUCTION  Sudden hearing loss (SHL) is an ENT emergency defined as sensorineural hearing loss (SNHL) ≥ 30 dB HL affecting at least 3 consecutive tonal frequencies, showing a sudden onset, and occurring within 3 days. In cases of SHL, a detailed investigation should be performed in order to determine the etiology and provide the best treatment.(More)
OBJECTIVE To identify novel genetic causes of syndromic hearing loss in Brazil. DESIGN To map a candidate chromosomal region through linkage studies in an extensive Brazilian family and identify novel pathogenic variants using sequencing and array-CGH. STUDY SAMPLE Brazilian pedigree with individuals affected by BO syndrome characterized by deafness and(More)
In mammals, damage to sensory receptor cells (hair cells) of the inner ear results in permanent sensorineural hearing loss. Here, we investigated whether postnatal mouse inner ear progenitor/stem cells (mIESCs) are viable after transplantation into the basal turns of neomycin-injured guinea pig cochleas. We also examined the effects of mIESC transplantation(More)