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Drug resistance in haemopoietic cells may be partly related to the expression of the glutathione-s-transferase (GST) pi and mdr-1 genes. We have used RNA slot blotting techniques to investigate the expression of GST pi in peripheral blood and bone marrow of eleven normal subjects, nine patients with myelodysplastic syndrome (MDS), eighteen patients with(More)
it was shown that human tumours could be grown subcutaneously in thym-ectomized, irradiated mice (900 rad), which had been reconstituted using 1 x 107 syn-geneic bone marrow cells. This method has justified its earlier promise, and tumour survivals of 42 months have now been experienced The tumours were obtained at operation from patients with primary(More)
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