Jeanine Van Herrewege

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Natural populations from France, several countries around the Mediterranean sea, tropical Africa and South Africa were investigated for ethanol tolerance and allelic frequencies at the Adh locus. Both traits exhibited a clinal pattern, i.e. an increase of tolerance and of the frequency of the Adh-F allele with latitude. Larvae exhibited variations in(More)
Three natural populations of D. melanogaster with different ethanol tolerance, and a population of D. simulans were successfully selected for an increased capacity to withstand alcohol. Alcohol utilisation, measured by the increase of life duration in the presence of low concentrations of alcohol, was clearly improved only in two cases. Alcohol tolerance(More)
When adult Drosophila are placed on medium containing 0.5% acetone, their level of alcohol dehydrogenase activity drops rapidly. At the same time, the proportion of activity in the various electrophoretic forms of the enzyme shifts; most of the activity becomes localized in what is ordinarily a minor form of the enzyme. Moreover, the loss of enzyme activity(More)
Metabolic utilization and toxicity of acetaldehyde were studied in flies lacking alcohol dehydrogenase (ADH), aldehyde oxidase (AO), or both functions. Prior to the experiments, mutant alleles Adhn4 and mal were transferred to the same genetic background by 10 successive backcrosses. By comparison with wild-type flies, various deleterious, pleiotropic(More)