Jean W. Tom

  • Citations Per Year
Learn More
The drug development process is a long complex multidisciplinary endeavor. Much of the activity to support the registration and manufacture of a new medicine is developed in the area known as chemistry, manufacturing, and controls (CMC) in reference to the common designation in regulatory filings. The Bristol-Myers Squibb (BMS) Pharmaceutical Development(More)
Human cultured monocyte-like tumor cells of the U-937 line, that are incubated for 24 h at 37 degrees C with 100 ng/ml of PMA, generate and release a fibroblast-activating factor (FAF) capable of enhancing the uptake of [3H]TdR by human dermal fibroblasts in vitro. The predominant FAF activity in unpurified supernatants from U-937 cells was associated with(More)
Polyhydroxy acids [poly(L-lactic acid) (L-PLA), poly(D,L-lactic acid) (DL-PLA), and poly-(glycolic acid) (PGA)], biocompatible and bioerodible polymers that are being investigated for controlled delivery of pharmaceuticals and are approved by the Food and Drug Administration for in vivo sutures and bone repair implants, have been dissolved in supercritical(More)
  • 1