Jean Tsou

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OBJECTIVE Atherosclerosis is a focal disease that develops at sites of low and oscillatory shear stress in arteries. This study aimed to understand how endothelial cells sense a gradient of fluid shear stress and transduce signals that regulate membrane expression of cell adhesion molecules and monocyte recruitment. METHODS Human aortic endothelial cells(More)
RATIONALE AND OBJECTIVES Improvements in the diagnosis of early breast cancers depend on a physician's ability to obtain the information necessary to distinguish nonpalpable malignant and benign tumors. Viscoelastic features that describe mechanical properties of tissues may help to distinguish these types of lesions. MATERIALS AND METHODS Twenty-one(More)
Wall shear rate (WSR) is the derivative of blood velocity with respect to vessel radius at the endothelial cell (EC) surface. The product of WSR and blood viscosity is the wall shear stress (WSS) that has been identified as an important factor for atherosclerosis development. High echo signal-to-noise ratio (eSNR) and high spatial resolution are crucial for(More)
Atherosclerotic lesions preferentially originate in arterial regions that experience low wall shear stress (WSS) and reversing flow patterns. Therefore, routinely monitoring arterial WSS may help to identify the potential sites of early atherosclerosis. A new noninvasive ultrasonic method implemented with coded excitation techniques was utilized to improve(More)
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