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Impacts of HIV infection on Vγ2Vδ2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS
HIV infection causes rapid and lasting defects in the population of Vγ2Vδ2 T cells. To fully describe the impact of HIV, we examined PBMC samples from HIV+ patients receiving highly activeExpand
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IBL4, A B cell line derived from an AIDS-related lymphoma, is a novel tumor stimulator and target for Vy2Vd2 T cell
Vg2Vd2 T cells are the predominant peripheral blood subset of – T cells and recognize tumor cells in a TCR-dependent, MHC-unrestricted manner. Following HIV infection there is a rapid and targetedExpand
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Natural viral suppressors of HIV-1 have a unique capacity to maintain γδ T cells
Objective:To evaluate Vγ2Vδ2 T cells in a group of HIV-infected patients who suppress HIV replication without antiretroviral therapy (natural viral suppressors, NVSs). Design:It is a cross-sectionalExpand
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HIV infection destabilizes a targeted subset of the gamma/delta T cell repertoire
The mature gamma/delta T cell receptor repertoire arises by a process of positive selection and amplification of cells expressing the Vg2Vd2 TCR, with further skewing to TCR with the Vg2-Jg1.2Expand
Loss and Recovery of Vg2Vd2 T cells in HIV/AIDS
HIV infection results in an early and profound loss of Vg2Vd2 T cells, and this is the only T cell receptor-specific depletion that is common to all individuals with HIV/ AIDS. A similar pattern ofExpand
Rapid Activation of an Effector Phenotype in Human Vγ2/Vδ2 T Cells Stimulated With a Toll-Like Receptor 2 (Tlr2) Agonist
Approximately 1–10% of circulating CD3+ cells in the blood express the gamma delta (γδ) T cell receptor (TCR) and, of these γδ T cells, the majority express the Vγ2/Vδ2 receptor. In HIV-infection,Expand