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BACKGROUND Anopheles gambiae is a major vector of malaria and lymphatic filariasis. The arthropod-host interactions occurring at the skin interface are complex and dynamic. We used a global approach to describe the interaction between the mosquito (infected or uninfected) and the skin of mammals during blood feeding. METHODS Intravital video microscopy… (More)
In malaria, mosquito saliva and salivary glands play central roles in the multi-faceted interactions that occur among the parasite, its vector, and its host. Analyzing the processes involved in the survival and maintenance of the Plasmodium parasite in mosquito organs, and in its transmission into vertebrate hosts, may lead to the identification of new… (More)
BACKGROUND Invasion of the mosquito salivary glands by Plasmodium is a critical step for malaria transmission. From a SAGE analysis, we previously identified several genes whose expression in salivary glands was regulated coincident with sporozoite invasion of salivary glands. To get insights into the consequences of these salivary gland responses, here we… (More)
An outbreak of human botulism was due to consumption of ham containing botulinum neurotoxins B and E. A Clostridium botulinum type E strain isolated from ham was assigned to a new subtype (E12) based on bont/E gene sequencing and belongs to a new multilocus sequence subtype, as analyzed by whole-genome sequencing.
We describe a case of post-operative intra-abdominal infection with Clostridium disporicum, a gram-positive anaerobic rod rarely isolated in clinical specimens. Its typical doubled-spored form, when present, facilitates its recognition. Phenotype-based identification methods used here were not reliable and a 16S rRNA sequence analysis was needed.
We report a case of foot infection by Clostridium sordellii and review 15 human infections registered at a Reference Center in France during the period 1998 to 2011. All strains were found nontoxigenic, lacking the lethal toxin gene coding for TcsL. Like Clostridium septicum, several C. sordellii infections were associated with intestinal neoplasms.
Christelle Mazuet1, Jean Sautereau1, Christine Legeay1, Christiane Bouchier2, Philippe Bouvet1, Nathalie Jourdan da Silva3, Christine Castor4 and Michel R Popoff1* 1Institut pasteur, Bactéries anaérobies et Toxines, Paris, France, 2Institut pasteur, Plateforme Génomique, Paris, France, 3French institute of public health, Department of infectious disease,… (More)
18 An outbreak of human botulism was due to consumption of ham containing botulinum 19 neurotoxins B and E. Clostridium botulinum type E strain isolated from ham was assigned to 20 a new subtype (E12) based on bont/E gene sequencing and belongs to a new multi locus 21 sequence subtype as analyzed by whole genome sequencing. 22
Up until now, Bacteroides faecis, a Gram-negative, anaerobic, non-motile, nonsporeforming rod has been principally described as a commensal microbe isolated from the feces of healthy adults. We report the first case of human Bacteroides faecis sepsis after removal of suspected post-colonic ischemia colonized epicardic electrodes. Electrodes and blood… (More)
The clinical course of a case of infant botulism was characterized by several relapses despite therapy with amoxicillin and metronidazole. Botulism was confirmed by identification of botulinum toxin and Clostridium botulinum in stools. A C. botulinum A2 strain resistant to penicillins and with heterogeneous resistance to metronidazole was isolated from… (More)