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Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I
The scavenger receptor class B type I (SR‐BI), which mediates selective cellular cholesterol uptake from high‐density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. TheExpand
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The CDK4–pRB–E2F1 pathway controls insulin secretion
CDK4–pRB–E2F1 cell-cycle regulators are robustly expressed in non-proliferating β cells, suggesting that besides the control of β-cell number the CDK4–pRB–E2F1 pathway has a role in β-cell function.Expand
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Expression of the liver X receptor α and β in embryonic and adult mice
We characterized the expression pattern of the nuclear receptors liver X receptor (LXR) alpha and beta during mouse embryonic development and in adulthood by in situ hybridization experiments.Expand
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Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
We have discovered and developed a series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma cells tested,Expand
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Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
Graphical Abstract Highlights d HA15 is a molecule that targets specifically BiP/GRP78/ HSPA5 d HA15 induces ER stress leading to cancer cell death in vitro and in vivo d HA15 overcomes BRAFExpand
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Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions
The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. With beta cellExpand
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Ligand‐dependent contribution of RXRβ to cholesterol homeostasis in Sertoli cells
We show that mice expressing retinoid X receptor β (RXRβ) impaired in its transcriptional activation function AF‐2 (Rxrbaf20 mutation) do not display the spermatid release defects observed inExpand
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The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate
Elevation of the dietary saturated fatty acid palmitate contributes to the reduction of functional beta cell mass in the pathogenesis of type 2 diabetes. The diabetogenic effect of palmitate isExpand
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Cell cycle regulators in the control of metabolism
We recently showed that the CDK4-pRB-E2F1 cell cycle regulators directly regulate the expression of Kir6.2, which is a key component of the KATP channel involved in the regulation of glucose-inducedExpand
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Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes
Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt their secretory capacity to compensate the elevated glycaemia and the peripheral insulin resistance.Expand
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