Jean Pierre Nakache

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We describe an index of functional impairment and a system of scoring joint tenderness for use in the assessment of ankylosing spondylitis. The functional index consists of 20 questions and the articular index is based on the scoring of a total of 10 joint responses after movement or firm digital pressure. These indices are simple to establish and not time(More)
OBJECTIVE To consider the relevance of the duration of a clinical trial in ankylosing spondylitis: long-term (i.e. 1 yr) vs short-term (i.e. 6 weeks) assessment of a non-steroidal anti-inflammatory drug (NSAID)-placebo controlled study. METHODS The design was a prospective, multicentre, double-blind, placebo-controlled study of 6 weeks duration with a 12(More)
OBJECTIVE Disease activity has been defined using a self-administered instrument, focusing on fatigue, axial pain, peripheral pain, enthesopathy and morning stiffness [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)]. This validated instrument is simple and takes 40 s to complete, but whether the index is an accurate expression of the component(More)
BACKGROUND A composite index would help in medical practice for considering total hip replacement (THR) in hip osteoarthritis. In association with other parameters, such as age or general status, this index could serve to objectively determine the time to THR surgery, and might be used as an outcome measure in therapeutic trials. The objective of this study(More)
This paper concerns the prediction of fetal Down's syndrome in pregnant women. Down's syndrome is the most common congenital cause of severe mental retardation. We elaborate two predictive functions of trisomy 21, combining maternal age and a maternal serum marker. We evaluated them by means of receiver operating characteristic (ROC) curves which give a(More)
STUDY OBJECTIVE to identify homogeneous, distinct subgroups of osteoarthritis patients based on distribution of osteoarthritis lesions. PATIENTS-METHODS STUDY DESIGN cross-sectional, prospective, multicenter. Patients with osteoarthritis of the hip, knee, fingers, or spine. DATA COLLECTED clinical and radiologic features at 41 joint sites. METHODS(More)
To assess the additional value of multiplanar reformations (MPR) in comparison with axial images alone for location of the transition zone in CT of mechanical small-bowel obstruction (SBO). Sixty-nine consecutive patients with mechanical SBO underwent 16-slice multi detector row CT (MDCT). The gold standard for the precise location of the transition zone(More)
Plasma CEA was measured in 776 institutionalized elderly patients, 593 women and 183 men, whose mean age was 80.8 +/- 9.7 yr. Of these subjects 39 were found to be free of any pathology and were considered as a control group. All the other subjects had a variety of diseases, malignant or not, known or not known to be associated with elevated CEA. This study(More)
The methods of discrimination on qualitative variables are generally based on the estimation of density distribution in each group yk (k = 1, 2, ..., K). Two kinds of estimation are proposed and the correspondent computer program is presented. The results of a medical example are compared with those obtained by using a logistic model used by different(More)