Jean-Pierre Maufroid

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Wild type embryos of the newt Pleurodeles waltl were used to realize parabiosis, a useful model to study the effect of endogenous circulating hormones on gonad development. The genotypic sex of each parabiont (ZZ male or ZW female) was determined early from the analysis of the sex chromosome borne marker peptidase-1. In ZZ/ZZ and ZW/ZW associations, gonads(More)
The effect of dipeptides known to inhibit the ubiquitin-mediated proteolysis has been examined on growth factor induced neurite outgrowth from amphibian neuroepithelial precursor cells in primary culture. Nerve growth factor (NGF) stimulated neuritogenesis from these cells but fibroblast growth factor 2 (FGF-2) only increased the number of melanophores. The(More)
Animal, vegetal, dorsal and ventral blastomeres of eight-cell embryos of the urodele Pleurodeles waltlii were isolated and cultured for 15 days. The four animal blastomeres produced vesicles delimited by an irregularly shaped epidermis. In all other explants, the formation of mesodermal structures occurred, which can be interpreted as the result of(More)
Blastulae ectoderm is combined with dorsal or ventral endoderm from blastulae, gastrulae and early neurulae. In vitro culture reveals the presence of different mesodermal structures whose nature is connected with the endoderm origin site. Primordial germ cells differentiate essentially in the recombinates including ventral endoderm. The inducing capacity of(More)
The ventro-lateral amphibian mesoderm is the presumptive area of blood cells, lateral plates and mesenchyme. To these mesodermal derivatives primordial germ cells (PGCs) must be added in the urodeles. Mesoderm and PGCs are formed from ectodermal cap of the gastrula under inductive influence of ventral endoderm. The present study was carried out to(More)
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