Jean-Pierre Landesman

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Crocidolite and chrysotile asbestos and the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), induce ornithine decarboxylase (ODC) in hamster trachéalepithelial cells (HTEB). When added at the time cells were plated, non-growthinhibitory amounts of crocidolite (0.64 to 1.28 ,ug/sq cm) and chrysotile (0.064 to 0.13 fig/sq cm) asbestos increased(More)
The incidence of bronchogenic carcinoma is increased substantially in asbestos workers who smoke. We used several approaches to determine possible mechanisms of synergism at the cellular level between asbestos and the polycyclic aromatic hydrocarbon (PAH), benzo(a)pyrene (BaP), a chemical carcinogen in cigarette smoke. Specifically, we hypothesized that(More)
I . Copper deficiency was induced in newly hatched chicks by feeding on a milk-based diet for 12 d ; effects of supplementation with ascorbic acid were studied. 2. Cu deficiency alone resulted in 30% mortality from aortic rupture. This was associated with a 20% increase in total acid mucopolysaccharides in the aorta, manifested as an increase in chondroitin(More)
Chrysotile asbestos interacts with mucin-secreting cells of tracheal organ cultures, causing an increase in secretion of mucin into the culture medium. This response occurs in the absence of obvious morphologic damage to tracheal epithelial cells. We speculated that asbestos-induced hypersecretion was regulated by the interaction of fibers with specific(More)