Jean-Pierre Landesman

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Crocidolite and chrysotile asbestos and the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), induce ornithine decarboxylase (ODC) in hamster trachéalepithelial cells (HTE-B). When added at the time cells were plated, non-growth-inhibitory amounts of crocidolite (0.64 to 1.28 ,ug/sq cm) and chrysotile (0.064 to 0.13 fig/sq cm) asbestos increased(More)
The incidence of bronchogenic carcinoma is increased substantially in asbestos workers who smoke. We used several approaches to determine possible mechanisms of synergism at the cellular level between asbestos and the polycyclic aromatic hydrocarbon (PAH), benzo(a)pyrene (BaP), a chemical carcinogen in cigarette smoke. Specifically, we hypothesized that(More)
Chrysotile asbestos interacts with mucin-secreting cells of tracheal organ cultures, causing an increase in secretion of mucin into the culture medium. This response occurs in the absence of obvious morphologic damage to tracheal epithelial cells. We speculated that asbestos-induced hypersecretion was regulated by the interaction of fibers with specific(More)