Jean-Pierre Landesman

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The incidence of bronchogenic carcinoma is increased substantially in asbestos workers who smoke. We used several approaches to determine possible mechanisms of synergism at the cellular level between asbestos and the polycyclic aromatic hydrocarbon (PAH), benzo(a)pyrene (BaP), a chemical carcinogen in cigarette smoke. Specifically, we hypothesized that(More)
Chrysotile asbestos interacts with mucin-secreting cells of tracheal organ cultures, causing an increase in secretion of mucin into the culture medium. This response occurs in the absence of obvious morphologic damage to tracheal epithelial cells. We speculated that asbestos-induced hypersecretion was regulated by the interaction of fibers with specific(More)
The components used in the automotive environment are subjected during their lives to various environmental combined stresses. The predominant failure mechanism at the package level due to these combined stresses is the ball bond lift. The failure is due to the combination of metallurgical effects, such as the intermetallic (IMC) Au-Al thickness growth,(More)
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