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Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.
Increased translocation of intestinal bacteria is a hallmark of chronic liver disease and contributes to hepatic inflammation and fibrosis. Here we tested the hypothesis that the intestinal… Expand
Fate-tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its etiology
- I. Mederacke, Christine C. Hsu, +5 authors R. Schwabe
- Biology, Medicine
- Nature communications
- 22 November 2013
Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the lack of detailed knowledge about specific cellular contributors mediating fibrogenesis hampers the design… Expand
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
- P. Huebener, Jean-Philippe Pradère, +7 authors R. Schwabe
- The Journal of clinical investigation
In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns (DAMPs) are considered key inducers of… Expand
Deactivation of hepatic stellate cells during liver fibrosis resolution in mice.
- Juliane S. Troeger, I. Mederacke, +6 authors Robert F. Schwabe
- Biology, Medicine
- 1 October 2012
BACKGROUND & AIMS Activated hepatic stellate cells (HSCs), the main fibrogenic cell type in the liver, undergo apoptosis after cessation of liver injury, which contributes to resolution of fibrosis.… Expand
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
- Jean-Philippe Pradère, Johannes Kluwe, +10 authors Robert F. Schwabe
- Medicine, Biology
- 1 October 2013
Although it is well established that hepatic macrophages play a crucial role in the development of liver fibrosis, the underlying mechanisms remain largely elusive. Moreover, it is not known whether… Expand
S32826, A Nanomolar Inhibitor of Autotaxin: Discovery, Synthesis and Applications as a Pharmacological Tool
- G. Ferry, N. Moulharat, +11 authors J. Boutin
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 December 2008
Autotaxin catalyzes the transformation of lyso-phosphatidylcholine in lyso-phosphatidic acid (LPA). LPA is a phospholipid possessing a large panel of activity, in particular as a motility factor or… Expand
Lysophosphatidic acid and renal fibrosis.
- Jean-Philippe Pradère, J. Gonzalez, +6 authors J. Schanstra
- Biology, Medicine
- Biochimica et biophysica acta
- 1 September 2008
The development of fibrosis involves a multitude of events and molecules. Until now the majority of these molecules were found to be proteins or peptides. But recent data show significant involvement… Expand
Toll-like receptor 4 and hepatic fibrogenesis.
- Jean-Philippe Pradère, Juliane S. Troeger, D. H. Dapito, Ali A Mencin, R. Schwabe
- Seminars in liver disease
- 21 July 2010
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as… Expand
The miR‐379/miR‐410 cluster at the imprinted Dlk1‐Dio3 domain controls neonatal metabolic adaptation
In mammals, birth entails complex metabolic adjustments essential for neonatal survival. Using a mouse knockout model, we identify crucial biological roles for the miR‐379/miR‐410 cluster within the… Expand
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis
Objective Hepatic stellate cells (HSCs) contain a number of bioactive metabolites or their precursors including retinoids in their characteristic lipid droplets. The loss of lipid droplets and… Expand