Jean-Philippe Drouhard

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The purpose of this paper is to revise the parameters of the Hodgkin-Huxley formulation for the Na+ current in ventricular myocardial cells. To this end we have assembled much of the recent voltage clamp data on cardiac preparations obtained with modern voltage clamp and patch clamp techniques. The selected activation and inactivation characteristics of the(More)
A comparison between traditional numerical integration methods and a new hybrid integration method for the reconstruction of action potential activity is presented, using a mathematical model of the cardiac Purkinje fiber (MNT model). It is shown that the hybrid integration method reduces importantly the overall computation time required for solving the(More)
Relative changes in the sodium conductance of the resting cardiac cell membrane are often estimated from relative changes in the maximum rate of rise of the action potential (Vmax). This approach has given rise to some controversy and it has not been possible so far to test it directly on an experimental basis. We have examined here the validity of this(More)
We propose to address the problem of how to know students’ knowledge in an entirely new approach called “epistemography” which is, roughly, an attempt to describe the structure of this knowledge. We claim that what is to be known is made of five tightly interrelated organised systems: the mathematical universe, the system of semio-linguistic(More)
1. The sodium and potassium conductances of the HODGKIN-HUXLEY model are simulated by a field effect transistor with a series resistor. This arrangement leads to a simple analog model of the excitable membrane (fig. 1 and 2). 2. Normally, the model is silent (fig. 3), but it becomes automatic (fig. 4) when the decay time (de-activation) of the potassium(More)
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