Jean Philippe Deslys

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The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely consequence of human dietary exposure to Bovine Spongiform Encephalopathy (BSE) agent. More recently, secondary vCJD cases were identified in patients transfused with blood products prepared from apparently healthy donors who later went on to develop the disease. As there is no(More)
Prions are known to be formed by β-sheet-rich amyloid fibrils. Their detailed structural architecture, however, is still obscure due to the failure of biophysical structure analysis on insoluble, non-crystalline and heterogeneous protein fibrils, not amenable to X-ray crystallography and liquid-state NMR. Since all model concepts available to date are based(More)
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