Jean-Philippe Baguet

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OBJECTIVE Vascular impairment, a main feature of the pathogenesis of systemic sclerosis (SSc), involves both the macro- and the microvasculature. We compared and correlated simultaneously measured skin microvascular and brachial artery macrovascular post-occlusive hyperemia in 3 groups: patients with SSc, patients with primary Raynaud's phenomenon (RP), and(More)
Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder leading to cardiovascular and metabolic complications. OSA is also a multicomponent disorder, with intermittent hypoxia (IH) as the main trigger for the associated cardiovascular and metabolic alterations. Indeed, recurrent pharyngeal collapses during sleep lead to repetitive sequences of(More)
BACKGROUND Obesity hypoventilation syndrome (OHS) is associated with increased cardiovascular morbidity. What moderate chronic hypoventilation adds to obesity on systemic inflammation and endothelial dysfunction remains unknown. QUESTION To compare inflammatory status and endothelial function in OHS versus eucapnic obese patients. METHODOLOGY 14 OHS and(More)
Obstructive sleep apnea (OSA) is associated with high cardiovascular morbidity and mortality. Recent studies have shown that it is associated with atherosclerosis and left ventricular dysfunction markers. The aim of this study was to assess the cardiovascular effects of OSA depending on its severity, in patients without clinically diagnosed cardiovascular(More)
BACKGROUND The higher mortality rate in untreated patients with obesity-associated hypoventilation is a strong rationale for long-term noninvasive ventilation (NIV). The impacts of comorbidities, medications and NIV compliance on survival of these patients remain largely unexplored. METHODS Observational cohort of hypercapnic obese patients initiated on(More)
OBJECTIVE To assess whether nocturnal blood pressure dipping status in type 1 diabetes is correlated with specific sleep characteristics and differences in nocturnal glycemic profiles. RESEARCH DESIGN AND METHODS Twenty type 1 diabetic adult patients underwent sleep studies with simultaneous 24-h ambulatory blood pressure monitoring and continuous(More)
Cardiovascular diseases are the most common cause of mortality in chronic obstructive pulmonary disease (COPD) [1]. Arterial stiffness certainly plays a role in the increased cardiovascular risk of these patients [2, 3]. Arterial pulse wave velocity (PWV) constitutes a useful and safe non-invasive method [4] for assessing central arterial stiffness. The(More)
RATIONALE Accumulated evidence implicates sympathetic activation as inducing oxidative stress and systemic inflammation, which in turn lead to hypertension, endothelial dysfunction, and atherosclerosis in obstructive sleep apnea (OSA). Statins through their pleiotropic properties may modify inflammation, lipid profile, and cardiovascular outcomes in OSA. (More)
PURPOSE To study the effect on intraocular pressure (IOP) of a sudden increase in blood pressure (BP) and of changes in partial pressure of CO(2) (pCO(2)). METHODS Two experimental studies were conducted: in pigs (n = 7), where BP was reduced by intravenous injection of sodium nitroprusside and increased by injection of angiotensin II; and in humans (n =(More)
OBJECTIVE Sleep restriction has been associated with deteriorated insulin sensitivity. The effects of short sleep duration have been explored little in patients with type 1 diabetes. This study addresses the question of whether sleep curtailment affects HbA1c levels in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS Seventy-nine adult patients(More)