Jean-Paul Rolland

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In eubacteria, translation of defective messenger RNAs (mRNAs) produces truncated polypeptides that stall on the ribosome. A quality control mechanism referred to as trans-translation is performed by transfer-messenger RNA (tmRNA), a specialized RNA acting as both a tRNA and an mRNA, associated with small protein B (SmpB). So far, a clear view of the(More)
BACKGROUND INFORMATION Hsp90 (90 kDa heat-shock protein) plays a key role in the folding and activation of many client proteins involved in signal transduction and cell cycle control. The cycle of Hsp90 has been intimately associated with large conformational rearrangements, which are nucleotide-binding-dependent. However, up to now, our understanding of(More)
  • Emilie Fournier, Vincent Moules, Boris Essere, Jean-Christophe Paillart, Jean-Daniel Sirbat, Catherine Isel +5 others
  • 2012
The influenza A virus genome consists of eight viral RNAs (vRNAs) that form viral ribonucleoproteins (vRNPs). Even though evidence supporting segment-specific packaging of vRNAs is accumulating, the mechanism ensuring selective packaging of one copy of each vRNA into the viral particles remains largely unknown. We used electron tomography to show that the(More)
'IBIS' is a set of computer programs concerned with the processing of electron micrographs, with particular emphasis on the requirements for structural analyses of biological macromolecules. The software is written in FORTRAN 77 and runs on Unix workstations. A description of the various functions and the implementation mode is given. Some examples(More)
IBIS is a set of computer programs dedicated to the processing of electron micrographs, mainly for structural analysis of biological macromolecules. We present IBIS version 3, a UNIX/OSF/Motif 1.2-based package which carries out and provides visual display of the many operations essential to image analysis. To ensure portability, the software is written in(More)
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