Jean Paul Levy

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BACKGROUND Omalizumab has been shown to decrease the risk of hospitalization or ED visits in patients with uncontrolled severe allergic asthma compared with placebo. This longitudinal study observed the conditions under which omalizumab is prescribed in real-life settings and assessed whether its use as an add-on therapy alongside standard treatments(More)
T-lymphocyte clones specific for the influenza A/Texas virus were obtained by limiting dilution of activated T cells from an HLA A2/3, B7/39, Cw -/-, DR2-short/2 short, DQw1/w1, DwFJO/FJO donor. Among the proliferating clones studied, and irrespective of their antigenic specificities, most of them were restricted by epitope(s) on HLA-DR molecules present(More)
By the use of MLR with homozygous typing cells, three subtypes in the HLA-DRw8 haplotype have been described: Dw8.1, Dw8.2, and Dw8.3 (Grosse-Wilde et al. 1984). The heterogeneity of this haplotype has been also suggested by serology (Betuel et al. 1984), cellular typing (Mickelson et al. 1983, Herrera et al. 1985), and biochemical analysis (Baldwin et al.(More)
A human T-cell line, B3, has been obtained by cloning spleen cells at limiting dilutions in the presence of influenza-A-virus-infected autologous cells. B3 cells were OKT 3+4+8−, E rosetting+, Sig− and were HLA-DR (+) after stimulation and HLA-DR (−) when resting. They proliferate specifically in the presence of influenza-virus-infected cells. Remarkable is(More)
Flow thermolysis of strictamine (1) generated two of the predictable rearrangement products, resulting from [1,5]-sigmatropic shifts: akuammicine (2) and indolenine 9. Besides formation of these two compounds, a quite different pathway gave rise to a novel rearrangement leading to indole 6, with the framework of the natural alkaloid ngouniensine (19).(More)
The cytolysis of 3H-proline-labelled tumour cells growing in monolayer by syngeneic immune lymphocytes has been studied in the murine sarcoma virus (MSV) system. Results show that the proline assay (PA) is a convenient way to reveal the activity of cytolytic T lymphocytes against FMR-like antigens. Using the same effector and target cells, the classical(More)