Jean-Paul Delage

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A 55-year-old woman with eosinophilic fasciitis was biopsied 8 weeks after the onset of her illness. Under the electron microscope the changes were almost exclusively located in the fascia with many active fibroblasts, accumulation of protocollagen fibrils (10–50 Å diameter), elastic fibre remodelling and numerous degranulating mast cells. The inflammatory(More)
Many muscular diseases result from abnormal organization of connective tissue and/or collagen network formation. Only a few molecular imaging techniques are able to analyze this collagen network by differentiating collagen types. In this study, FT-IR spectroscopy was used to analyze type I and IV collagens, the most important compounds of which are(More)
BACKGROUND Local anesthetics offer the benefits of extended analgesia with greater patient satisfaction and faster rehabilitation compared with intravenous morphine. These benefits, however, can be offset by adverse iatrogenic muscle pain caused by bupivacaine. Here, the authors describe the mechanisms of local anesthetic-induced myotoxicity and a partial(More)
N cyclohexyl-N-methyl-2 amino -3.5 dibromobenzyl, amine hydrochloride or Bisolvon is an alkaloid derived from vasicine whose fluidizing effects on bronchial secretions are well-known. This study which consisted in a randomization involved 40 patients that were being submitted to a respiratory reanimation, half of whom received Bisolvon intravenously. The(More)
An ultrastructural study of distal human fetal lung between the fifteenth and nineteenth weeks of gestation is performed. All the cells of the epithelial lining layer have an endodermal origin and are provided by one cellular pattern: the columnar undifferentiated cell. From nineteenth week of gestation a differentiation into alveolar et bronchiolar ways is(More)