Jean-Paul Brun

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This study examined the effects, after 1 min or 2 hr, of one footshock session on the activity of MAO in rat heart and brain, the MAO inhibitory activity of these tissues, and the animal's behavior in an open field. Internal ambulation was reduced at both times; the lowest score was registered at 1 min. The number of boluses emitted during the test was(More)
INTRODUCTION In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tried to characterize in vitro monocyte(More)
INTRODUCTION The overall prognosis of critically ill patients with cancer has improved during the past decade. The aim of this study was to identify early prognostic factors of intensive care unit (ICU) mortality in patients with cancer. METHODS We designed a prospective, consecutive, observational study over a one-year period. Fifty-one cancer patients(More)
BACKGROUND Gastrointestinal (GI) symptoms, such as nausea, vomiting, bloating, postprandial fullness, and abdominal pain, are frequent in patients with diabetes mellitus (DM). The pathogenesis is complex and multi-factorial. To determine easy accessible and valid biomarkers for disordered GI function in DM patients, we aimed to study esophageal mechanical(More)
An important controversy in the relationship between beef tenderness and muscle characteristics including biochemical traits exists among meat researchers. The aim of this study is to explain variability in meat tenderness using muscle characteristics and biochemical traits available in the Integrated and Functional Biology of Beef (BIF-Beef) database. The(More)
BACKGROUND Clinical data suggest gender differences in gastrointestinal pain, but very little experimental data exist. Esophageal painful thresholds to mechanical, thermal, electric, and chemical stimuli can be measured with the esophageal multimodal pain model. The aim was to measure the effect of gender and mild esophagitis on esophageal pain perception.(More)
The effects of predictable or unpredictable shocks on ambulation, pain sensitivity, plasma catecholamines and heart and brain monoamine oxidase (MAO) inhibitory activity were investigated in rats. Animals showed plasma catecholamines and heart MAO inhibitory activity sensitization irrespective of type of treatment, while differences between groups were(More)
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