Jean-Paul Brun

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This study examined the effects, after 1 min or 2 hr, of one footshock session on the activity of MAO in rat heart and brain, the MAO inhibitory activity of these tissues, and the animal's behavior in an open field. Internal ambulation was reduced at both times; the lowest score was registered at 1 min. The number of boluses emitted during the test was(More)
BACKGROUND In severe sepsis, guidelines recommend de-escalating the empirical antimicrobial treatment as soon as the microbiological results are available. We aimed to determine the rate of de-escalation of the empirical antimicrobial treatment in neutropenic patients with severe sepsis. The characteristics of antimicrobial treatment associated with(More)
INTRODUCTION In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tried to characterize in vitro monocyte(More)
INTRODUCTION The overall prognosis of critically ill patients with cancer has improved during the past decade. The aim of this study was to identify early prognostic factors of intensive care unit (ICU) mortality in patients with cancer. METHODS We designed a prospective, consecutive, observational study over a one-year period. Fifty-one cancer patients(More)
The effects of predictable or unpredictable shocks on ambulation, pain sensitivity, plasma catecholamines and heart and brain monoamine oxidase (MAO) inhibitory activity were investigated in rats. Animals showed plasma catecholamines and heart MAO inhibitory activity sensitization irrespective of type of treatment, while differences between groups were(More)
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