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Following intratracheal injection of particles of colloidal gold (30 nm) in the rat, particles in the blood platelets of the alveolar capillaries can rapidly be observed. The presence of the gold is confirmed by microanalysis. The role of this phenomenon in pulmonary clearance is discussed.
Some nickel compounds (Ni3S2,Ni) induce tumours in muscle, while others have no effect (NiO). It has been suggested that the carcinogenicity of nickel is related to its penetrating power (phagocytosis) in transformed cells. The penetration of various nickel salts into cultured rhabdomyosarcoma cells (RhC) was studied. Electron microscopy and microanalysis(More)
This paper presents the current status of the development of an autonomous blimp. Details are given on the hardware setup, which is currently almost operational. Some first experimental results on terrain mapping terrain mapping with low altitude stereo imagery are presented and discussed, and some insights regarding flight control developments are given.(More)
The progressive transformation of illite crystals in alveolar macrophages has been studied with x-ray microanalysis and electron microdiffraction. Illite particles captured by macrophages undergo a series of progressive modifications which affect their ultrastructure, crystalline state, and chemical composition. Crystalline structure progressively(More)
After treating rats with potassium bichromate, x-ray microanalysis of the proximal renal tubule cells demonstrated the presence of chromium in intracellular vacuoles. The lysosomal nature of these vacuoles is shown by the visualization of acid phosphatase activity. Chromium is concentrated both in the autolytic vacuoles and in their residual forms. The(More)
The use of complex platinum salts (Cis-DDP) in antitumoral therapy is well known. However the mode of action of this salt remains unknown. The present study was performed with human transformed cells in culture (WI-98-VAD), grown in the presence of Cis-DDP. The intracellular localization of platinum was studied by associating the technique of microanalysis(More)
Ion microscopy is a microanalytical method by which one can obtain distribution images of any chemical element with isotope discrimination even at very low local concentrations, in successive slices of the specimen. These images are obtained at the price of progressive erosion of the specimen, so that the analysis may not be replayed and it is necessary to(More)
In order to study the relationship between amiodarone-induced hepatic phospholipidosis and liver disease, liver biopsies obtained from 13 patients treated with amiodarone for 4 months to 15 years were investigated by light and electron microscopy. Light microscopy showed pseudoalcoholic liver lesions that were probably related to amiodarone in four cases,(More)
The incorporation of gallium in tumor cells in vitro and in solid tumors was studied with electron microscopy and two microanalytical techniques. It was thus possible (1) to directly prove that gallium is concentrated in lysosomes of tumor cells; (2) to demonstrate that in these lysosomes, gallium is precipitated with phosphorus; and (3) to propose a(More)
Brain tissue from the frontal cortex and hippocampal formation, taken at autopsy or biopsy from 7 patients with Alzheimer's disease, was studied by two methods of microanalysis. One case of Down's syndrome was also studied. Electron probe microanalysis of the frontal cortex and Ammon's horn of the hippocampus showed no aluminium in the various cell(More)