Jean Paul Armspach

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The automatic analysis of subtle changes between MRI scans is an important tool for assessing disease evolution over time. Manual labeling of evolutions in 3D data sets is tedious and error prone. Automatic change detection, however, remains a challenging image processing problem. A variety of MRI artifacts introduce a wide range of unrepresentative changes(More)
A probabilistic deformable model for the representation of multiple brain structures is described. The statistically learned deformable model represents the relative location of different anatomical surfaces in brain magnetic resonance images (MRIs) and accommodates their significant variability across different individuals. The surfaces of each anatomical(More)
In vivo measurement of T2 relaxation times in multiple sclerosis (MS) lesions by magnetic resonance imaging (MRI) is potentially useful for the evaluation of the disease activity. Seven patients with definite MS were investigated over a period of three years (19 examinations), using a whole-body MRI scanner operating at 0.15 T with a specially designed(More)
Blood--brain barrier permeability in myelin basic protein (MBP)-specific T cell induced experimental allergic encephalomyelitis (EAE) was studied by magnetic resonance imaging (MRI) in Lewis rats. Myelin basic protein-specific T cells of different specificity and/or purified protein derivative (PPD)-specific T cells were used. During the course of EAE, the(More)
This paper describes a robust, fully automated algorithm to register intrasubject 3D single and multimodal images of the human brain. The proposed technique accounts for the major limitations of the existing voxel similarity-based methods: sensitivity of the registration to local minima of the similarity function and inability to cope with gross(More)
BACKGROUND AND PURPOSE Brain volume loss is currently a MR imaging marker of neurodegeneration in MS. Available quantification algorithms perform either direct (segmentation-based techniques) or indirect (registration-based techniques) measurements. Because there is no reference standard technique, the assessment of their accuracy and reliability remains a(More)
A combination of temporo-limbic hyperperfusion and extratemporal hypoperfusion was observed during complex partial seizures (CPS) in temporal lobe epilepsy (TLE). To investigate the clinical correlate of perfusion changes in TLE, we analyzed focal seizures of increasing severity using voxel-based analysis of ictal SPECT. We selected 26 pre-operative pairs(More)
In this paper an image-based method founded on mathematical morphology is presented in order to facilitate the segmentation of cerebral structures over large data bases of 3D magnetic resonance images (MRIs). The segmentation is described as an immersion simulation, applied to the modified gradient image, modeled by a generated 3D-region adjacency graph(More)
A dynamic in vivo study by MRI consisting of the measurement of relaxation times and in the visualization of the BBB permeability by Gd-DOTA was performed in an MBP-induced acute EAE model of Lewis rat. Fourteen rats were immunized with an MBP/CFA mixture, eight by CFA alone, and three control rats were used to test the harmless effect of repeatedly(More)
In this study we compared the results of visual analysis of MR imaging with T2 relaxation time mapping of the mesial structures in a group of 97 patients with cryptogenic temporal lobe epilepsy. All patients underwent a clinical neurological examination, neuropsychological investigation, prolonged video-EEG monitoring, SPECT imaging, MR imaging, and T2(More)