Jean - Paul Achkar

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PURPOSE Plasma levels of lysophospholipids were evaluated as potential biomarkers for colorectal cancer (CRC), where a highly reliable and minimally invasive blood test is lacking. PATIENTS AND METHODS Patients with CRC (n = 133) and control subjects (n = 125) were recruited through the Cleveland Clinic. Preoperative plasma samples were analyzed for(More)
Chronic inflammatory diseases, depending upon the duration and severity, are frequently associated with an increased risk of developing cancer. A classic paradigm is the enhanced risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD). Carcinogenesis is a multifactorial process that involves accumulation of genetic defects, protein(More)
The results of recently completed genome-wide association studies have advanced knowledge of infl ammatory bowel disease (IBD) genetics, including the identifi cation of over 30 genes or loci associated with Crohn ’ s disease (CD). The possibility of interactions between genes, referred to by the term epistasis , needs to be carefully considered as both(More)
The aim of the study was to define the clinical characteristics and outcome of patients found to have an undetected hepatocellular carcinoma (HCC) at liver transplantation. Patients who underwent liver transplantation and were found to have a hepatoma with a prior workup showing normal alpha-fetoprotein levels and no corresponding lesion on radiological(More)
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