• Publications
  • Influence
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.
Amyloid fibrils associated with Alzheimer's disease and a wide range of other neurodegenerative diseases have a cross beta-sheet structure, where main chain hydrogen bonding occurs betweenExpand
  • 160
  • 6
A helix-to-coil transition at the ε-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis
Processing of amyloid precursor protein (APP) by γ-secretase is the last step in the formation of the Aβ peptides associated Alzheimer's disease. Solid-state NMR spectroscopy is used to establish theExpand
  • 96
  • 4
Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.
Proteolysis of the β C-terminal fragment (β-CTF) of the amyloid precursor protein generates the Aβ peptides associated with Alzheimer's disease. Familial mutations in the β-CTF, such as the A21GExpand
  • 30
  • 1
Network Excitability Dysfunction in Alzheimer's Disease: Insights from In Vitro and In Vivo Models
UNLABELLED Recent reports have drawn attention to dysfunctions of intrinsic neuronal excitability and network activity in Alzheimer disease (AD). Here we review the possible causes of these basicExpand
  • 33
Critical Role of Aquaporins in Interleukin 1β (IL-1β)-induced Inflammation*
Background: Aquaporins are channels permeable to water, and they are essential for immune cell migration. Results: We demonstrate that aquaporin-mediated water fluxes are necessary for the NLRP3Expand
  • 31
Benzodiazepine receptors in human brain: Characterization, subcellular localization and solubilization
1. Benzodiazepine receptors have been characterized in human brain mainly using [3H]-Ro 15-1788 and [3H]-flunitrazepam. Both ligands present a very high affinity for the receptor sites (Kd values ofExpand
  • 5
Cloning of the cDNA from normal brain and brain of patients with Alzheimer's disease in the expression vector lambda GT 11
1. RNA was purified from postmortem human brains, and the poly A+ RNA was isolated by oligo dT cellulose. 2. Double stranded cDNA was synthesized using reverse transcriptase, RNAse H and DNAExpand
  • 11
Muscle denervation increases thyrotropin-releasing hormone (TRH) biosynthesis in the rat medullary raphe
To determine whether thyrotropin-releasing hormone (TRH) could exert a trophic role in ventral horn motor neurons, we examined the effect of muscle denervation with botulinum toxin A on TRH mRNA inExpand
  • 7
β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing
Familial mutations in C99 can increase the total level of the soluble Aβ peptides produced by proteolysis, as well as the Aβ42/Aβ40 ratio, both of which are linked to the progression of Alzheimer’sExpand
  • 7
Neuronal Function of the Amyloid Precursor Protein of Alzheimer's Disease
disease and offers ground for the development of a therapeutic strategy. As a first step for designing an inhibitor of Ab aggregation based on the mutated Ab sequence, we synthesized a peptideExpand