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The study of the interaction of non-steroidal anti-inflammatory drugs (NSAIDs) with several reactive oxygen species is of great interest in inflammatory conditions where an uncontrolled release of these potentially damaging intermediates has been documented. This study focused on the scavenging of three species (hydroxyl radical, hydrogen peroxide and(More)
The aim of this study was to evaluate the precision and accuracy of dual-energy X-ray absorptiometry (DXA) for measuring bone mineral content at different sites of the skeleton in rats. In vitro the reproducibility error was very small (<1%), but in vivo the intra-observer variability ranged from 0.9% to 6.0%. Several factors have been shown to affect in(More)
Selenium is a powerful antioxidant regulating the activity of the glutathione peroxidase enzymes, which catalyse the detoxification of hydrogen peroxide and organic hydroperoxides. Selenium deficiency has been implicated in the aetiopathogeny of Keshan disease, an endemic cardiomyopathy observed in China, and in other cases of congestive cardiomyopathy in(More)
  • Jean Néve
  • Journal of trace elements in medicine and biology…
  • 1995
This review concentrates on the differences in the effects on indicators of selenium (Se) status of different chemical forms proposed for Se supplementation in healthy subjects. Modifications in blood (plasma and erythrocyte) Se concentrations and in the Se-dependent glutathione peroxidase (GSH-Px) enzymatic activity, in plasma, erythrocytes and platelets,(More)
Selenium is one of the essential nutrients that may have beneficial effects on health at dietary intakes higher than the established Recommended Dietary Allowances in the United States. Dietary recommendations for this element have been the subject of much controversy, illustrating the difficulties involved in the definition of requirements based on the(More)
Selenium (Se) deficiency is linked with some cardiomyopathies. Its status was determined in 170 patients with chronic Chagas' disease from 2 Brazilian regions (Rio de Janeiro and Belo Horizonte), clinically stratified into groups as follows: indeterminate or asymptomatic (IND); cardiac asymptomatic (CARDa); cardiac symptomatic with moderate to severe heart(More)
Starting from the experimental design of the established ‘Zinc Tolerance Tests’, the absorption and distribution of the essential trace element zinc in humans was investigated in 10 subjects by performing a pharmacokinetic study of the serum zinc profile after oral administration of a pharmacological dose of the metal, i.e. 0.69 mmol (45 mg) zinc as ZnSO4.7(More)
Oxidized low-density lipoproteins (LDL) accumulate in the vascular wall and promote a local inflammatory process contributing to the progression of atheromatous plaque. The key role of myeloperoxidase (MPO) in this process has been documented and the enzyme has been involved in the oxidative modification of apolipoprotein B-100 in the intima and at the(More)
Three experiments were completed to examine the effect of masker duration and spectrum on forward-masked intensity discrimination. Four listeners participated in each experiment. Intensity discrimination was measured in quiet and in the presence of forward maskers using adaptive forced-choice procedures. The standard duration was either short (10 ms) or(More)
OBJECTIVE Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is a link between oxidative stress and cytokines. The present study aims at investigating the link between synovial MPO (and its products), interleukin (IL)-18, which(More)