Jean-Maurice Vergnaud

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This paper is concerned with oral dosage forms with controlled release based on the erosion of the polymer matrix. A numerical model taking all the facts into account, i.e., the kinetics of release and pharmacokinetic parameters of the drug, makes it possible to calculate the plasma drug level. Diagrams are built which connect the half life times obtained(More)
The pharmacokinetics of ciprofloxacin in plasma and lung tissue at steady-state (500 mg b.i.d.) were studied in 38 patients subjected to lung surgery for bronchial epithelioma. The mean characteristics of the patient population were: age = 60 years (range: 48-70), weight=70kg (47-95), height=165cm (range 160-170) and serum creatinine=85microM (range(More)
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