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BACKGROUND Hypertriglyceridemia is associated with increased risk of cardiovascular disease. Until recently, the importance of hepatic de novo lipogenesis (DNL) in contributing to hypertriglyceridemia was difficult to assess because of methodologic limitations. OBJECTIVE We evaluated the extent of the contribution by DNL to different conditions associated(More)
H ypoxia in obese adipose tissue (AT) plays an important role in the development of whole-body insulin resistance by inducing local inflammation and the release of proinflammatory cyto-kines (1). Yet, living at high altitude is associated with a lower prevalence of impaired fasting glucose and type 2 diabetes compared with living at low altitude (2).(More)
BACKGROUND Inadequate energy intake induces changes in endogenous glucose production (GP) to preserve muscle mass. Whether addition provision of dietary protein modulates GP response to energy deficit is unclear. The objective was to determine whether exercise-induced energy deficit effects on glucose metabolism are mitigated by increased dietary protein.(More)
INTRODUCTION Altered gut and pancreatic hormone secretion may bolster resolution of insulin resistance after Roux-en-Y gastric bypass (RYGB), but the independent effects of weight loss and hormonal secretion on peripheral glucose disposal are unknown. METHODS Two groups of nondiabetic morbidly obese patients were studied: RYGB followed by standardized(More)
OBJECTIVE The presence of large subcutaneous adipocytes in obesity has been proposed to be linked with insulin resistance and type 2 diabetes through the "adipose tissue expandability" hypothesis, which holds that large adipocytes have a limited capacity for expansion, forcing lipids to be stored in nonadipose ectopic depots (skeletal muscle, liver), where(More)
IMPORTANCE The identification of a patient with a rare form of severe dysbetalipoproteinemia allowed the study of the consequences of total absence of apolipoprotein E (apoE). OBJECTIVES To discover the molecular basis of this rare disorder and to determine the effects of complete absence of apoE on neurocognitive and visual function and on lipoprotein(More)
We previously reported that 10 nights of moderate hypoxia (;15% O 2 ; 10 h per night) improved glucose homeo-stasis (glucose disposal rate [GDR] during a hyperinsulinemic-euglycemic clamp) in obese men (1). Goossens (2) now raises some important questions about our study and puts forward an intriguing alternate hypothesis to explain our results that nightly(More)
Using stable isotopes in metabolic research with an emphasis on 13 C, 15 N or deuterated compounds offers a safe and reliable tool for metabolic profiling. Isotopic tracer studies coupled with the use of LC/MS, GC/MS and NMR allows researchers to investigate specific pathways involving glucose, fatty acids, amino acids and proteins. Doubly labeled water(More)
Using stable isotopes in metabolic research with an emphasis on 13 C, 15 N or deuterated compounds offers a safe and reliable tool for metabolic profiling. Isotopic tracer studies coupled with the use of LC/MS, GC/MS and NMR allows researchers to investigate specific pathways involving glucose, fatty acids, amino acids and proteins. Doubly labeled water(More)
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