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Chemical Quenching of Singlet Oxygen by Carotenoids in Plants1[C][W]
Carotenoids are considered to be the first line of defense of plants against singlet oxygen (1O2) toxicity because of their capacity to quench 1O2 as well as triplet chlorophylls through a physicalExpand
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HO• radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases
Reaction of HO• radicals with double-stranded calf thymus DNA produces high levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) and, to a minor extent, 8-oxo-7,8-dihydro-2′-deoxyadenosineExpand
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N6-methyladenine: the other methylated base of DNA.
Contrary to mammalian DNA, which is thought to contain only 5-methylcytosine (m5C), bacterial DNA contains two additional methylated bases, namely N6-methyladenine (m6A), and N4-methylcytosine (m4C).Expand
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Extranuclear protection of chromosomal DNA from oxidative stress
Eukaryotic organisms evolved under aerobic conditions subjecting nuclear DNA to damage provoked by reactive oxygen species (ROS). Although ROS are thought to be a major cause of DNA damage, little isExpand
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Undetectable levels of N6‐methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase
Three methylated bases, 5‐methylcytosine, N4‐methylcytosine and N6‐methyladenine (m6A), can be found in DNA. However, to date, only 5‐methylcytosine has been detected in mammalian genomes. ToExpand
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Oxidatively generated complex DNA damage: tandem and clustered lesions.
There is an increasing interest for oxidatively generated complex lesions that are potentially more detrimental than single oxidized nucleobases. In this survey, the recently available information onExpand
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Urinary levels of oxidative DNA and RNA damage among workers exposed to polycyclic aromatic hydrocarbons in silicon production: Comparison with 1‐hydroxypyrene
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous occupational and environmental pollutants and the urinary excretion of 1‐hydroxypyrene (1‐OHP) is classically measured for the determination ofExpand
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Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion
Bleomycin, a radiomimetic drug currently used in human cancer therapy, is a well known carcinogen. Its toxicity is mostly attributed to its potentiality to induce DNA double strand breaks likelyExpand
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Urinary excretion of 5‐(hydroxymethyl)uracil in healthy volunteers: Effect of active and passive tobacco smoke
The urinary excretion of 5‐(hydroxymethyl)uracil (5‐HMUra), one of the major oxidative modifications of thymine, was investigated in 134 healthy volunteers living in North Italy. Overnight urine wasExpand
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