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Syk Tyrosine Kinase Mediates Epstein-Barr Virus Latent Membrane Protein 2A-induced Cell Migration in Epithelial Cells*
TLDR
It is demonstrated that LMP2A expression can activate endogenous Syk activity and the LMP1A-Syk pathway may provide suitable drug targets for treatment of nasopharyngeal carcinoma. Expand
Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling.
TLDR
It is revealed that CD133(+) lung cancer cells labeled by a human CD133 promoter-driven GFP reporter exhibited drug resistance and stem cell characteristics, leading to multidrug resistance by the activation of Notch signaling. Expand
Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins.
TLDR
The data show that the viral LMP1 and Zta proteins regulate the expression and activity of MMP-1, and thereby confer the invasive properties of the cells. Expand
Defined culture conditions of human embryonic stem cells.
TLDR
A minimal medium containing basic fibroblast growth factor, Wnt3a, April, April (a proliferation-inducing ligand)/BAFF (B cell-activating factor belonging to TNF), albumin, cholesterol, insulin, and transferrin is developed, sufficient for hESC self-renewal and proliferation. Expand
Induction of the Early Growth Response 1 Gene by Epstein-Barr Virus Lytic Transactivator Zta
TLDR
It is shown that EBV reactivation is involved in upregulation of Egr-1 and that Egr -1 can be induced by Zta, an EBV lytic transactivator, and implies that Zta has the potential to affect expression of certain genes through E gr-1. Expand
Epstein-Barr Virus Latent Membrane Protein 2A Regulates c-Jun Protein through Extracellular Signal-Regulated Kinase
TLDR
It is suggested that LMP2A may exploit MAPK kinases and affect both the phosphorylation and stability of c-Jun protein, and may thereby promote the mobility of the cells. Expand
miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation.
TLDR
Novel functions of miR-200c and GATA4 in regulating hESC renewal and differentiation are uncovered and these functions are related to self-renewal and differentiation. Expand
RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma
TLDR
RBMY is a novel oncofetal protein that plays a key role in attenuating glycogen synthase kinase 3β activity, leading to aberrant activation of Wnt/β‐catenin signaling, which facilitates malignant hepatic stemness; because of its absence from normal human tissues except the testis, RBMY represents a feasible therapeutic target for the selective eradication of HCC cells in male patients. Expand
The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection
TLDR
The results indicated that uncontrolled viral replication leads to excessive production of inflammatory innate immune responses by accumulating CCR2+ inflammatory monocytes, which contribute to the fatal outcomes of high pathogenicity virus infections. Expand
Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts
TLDR
The first chemical method to convert primary human dermal fibroblasts into multipotent, induced MSC-like cells (iMSCs) is established, which can suppress LPS-mediated acute lung injury as effectively as bone marrow-derived mesenchymal stem cells. Expand
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