Jean-Louis Palgen

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The Paramyxoviridae family includes many viruses that are pathogenic in humans, including parainfluenza viruses, measles virus, respiratory syncytial virus, and the emerging zoonotic Henipaviruses. No effective treatments are currently available for these viruses, and there is a need for efficient antiviral therapies. Paramyxoviruses enter the target cell(More)
HTLV-1-mediated cellular transformation relies on Tax-dependent activation of the NF-B pathway, which has previously been shown to require Tax poly-ubiquitination and interaction with cellular factors, such as Optineurin (OPTN). The recent identification of OPTN as a selective autophagy receptor sharing high sequence similarities with sequestosome-1(More)
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