Jean Louis Pépin

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BACKGROUND Patients with narcolepsy-cataplexy (NC) mostly exhibit undetectable hypocretin levels. Hypocretin system is one of the key players in the complex interaction between sleep and the cardiovascular system. We tested the hypothesis that hypocretin deficiency affects cardiovascular risk factors by measuring nighttime and daytime ambulatory blood(More)
BACKGROUND Stable severe chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure treated by nocturnal bi-level positive pressure non-invasive ventilation (NIV) may experience severe morning deventilation dyspnea. We hypothesised that in these patients, progressive hyperinflation, resulting from inappropriate(More)
To investigate obstructive sleep apnea syndrome mechanisms, we developed a device to measure the surface electromyogram (EMG) time latency reflex of the genioglossus muscle stimulated by time and amplitude calibrated negative pharyngeal pressure drops. The reflex signals were found to be disturbed by transient signals that generate false alarms. Thus, to(More)
BACKGROUND Recent neuroimaging studies in humans support the clinical observations that the motor cortex is affected early in the course of Alzheimer's disease (AD). METHODS We used transcranial magnetic stimulation to measure the active cortical motor threshold (ACMT) in AD patients in the very early stage of the disease, and we explored whether and in(More)
Enhanced photic driving (PD) during high-frequency flicker stimulation, the so-called H response, is a classical feature of migraine patients between attacks, but is thought to be of poor clinical utility. Visual inspection of the EEG for its detection may not be reliable, however, data on its possible correlations with clinical features and migraine(More)
We have developed robust embedded algorithms for the real-time classification of activity detected by our wearable inertial device. We collected 224 h of accelerometric signals from 28 subjects [22 suffering from chronic obstructive pulmonary disease (COPD)] to develop and then evaluate our algorithms. We describe the process for determining the most robust(More)
BACKGROUND Recent neuroimaging studies in humans support the clinical observations that the motor cortex is affected early in the course of Alzheimer's disease (AD). PATIENTS AND METHODS We measured the silent period (SP) induced by transcranial magnetic stimulation in AD patients in the very early stage of the disease, and we explored whether and in(More)
Chronic Obstructive Pulmonary Disease (COPD) reduces airflow in and out of the lungs, causing dyspnea during physical exercises. Therefore it is interesting to monitor the blood saturation during a physical exercise. Such monitoring can benefit from a network of collaborative sensors. But to monitor the patient in his daily life, it is mandatory that the(More)
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