Jean-Louis Pépin

Publications21
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Chronic Ventilation in Obese Patients
Obesity, defined by a body mass index ≥30 kg/m2, has a major impact on respiratory health. Obesity-related chronic respiratory failure has become the primary cause for long-term home noninvasive… Expand
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Co-morbidities and cardiovascular medications are the best predictors of mortality in patients with obesity-associated hypoventilation treated with long-term non-invasive ventilation
Rationale: NIV is largely used to treat patients with obesity-associated hypoventilation (OH). The impact of comorbidities, their medications and NIV compliance on survival of these patients remain… Expand
Continuous positive airway pressure efficiency in apnoeic patients with resistant hypertension. Results from the randomised controlled RHOOSAS study
Objective Most of patients suffering from resistant hypertension (RH) have obstructive sleep apnea (OSA). However, little is known about the metabolic profile of these patients as well as the… Expand
Association Between Non Arteritic Anterior Ischaemic Optic Neuropathy And Sleep Apnoea Syndrome
Prevalence and diagnosis of obesity hypoventilation syndrome (OHS) in ambulatory obese patients
Background: Available data on the prevalence of OHS has mainly been obtained from cohorts of patients referred to sleep clinics but it remains unknown in unselected obese patients. Aims : i) To… Expand
Impact of cardiac sympathetic denervation on IH-induced ischemic cardiomyopathy aggravation
Chronic intermittent hypoxia induces features of non alcoholic fatty liver disease (NAFLD) and modifies adipose tissue characteristics in lean mice
Introduction: In human obesity, chronic intermittent hypoxia (CIH) due to obstructive sleep apnoea induces NAFLD exacerbation. Whether this remains true in non-obese OSA is still debated. By… Expand
Long-term noninvasive ventilation: do patients aged over 75 years differ from younger adults ?
Nocturnal hypoxemia, ambulatory blood pressure and chronic mountains sickness in the highest city in the world
Treatment of patients with complex and central sleep-disordered breathing with adaptive servo-ventilation (ASV): the READ-ASV registry