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The renal toxicity of combined administration of cyclosporin and aminoglycosides was evaluated in rats. Increasing doses of amikacin (A) or gentamicin (G) were injected alone or in association with cyclosporin (CS). Creatinine clearance rate, urinary N-acetyl-Beta-D-glucosaminidase (NAG) activity and NAG-B isoenzyme level were determined to evaluate(More)
Given the often reported relationships between sleep-wake regulation and the cerebral prostaglandins (PGs), the effect of chronic rapid eye movement (REM) sleep deprivation on brain PGE2 and PGD2 biosynthesis in mouse was evaluated, since they are known to have opposite actions as respectively wake- and sleep-inducing substances. Mice were subjected to 5(More)
Lysosomal enzyme activities can be modified by aminoglycosides. In this study, we have investigated the "in vitro" effect of gentamicin (G), tobramycin (T), dibekacin (D), netilmicin (N) and amikacin (AK) on urinary N-acétyl-beta-D-glucosaminidase (NAG) and its isoenzymatic forms. G, D and N are activators of this enzyme, specifically of the B isoenzymatic(More)
This study demonstrates that the retention behavior of various circular double-stranded DNA molecules (3, 5, and 10 kb) increases over the entire flow-rate range (0.02-1.8 mL/min) at all the mobile phase viscosities (h). The transition between the two well-known nonequilibrium chromatography methods (slalom and hydrodynamic chromatography) is clearly(More)
Our study indicates that amikacin (AK) inhibited urinary N-acetyl-beta-D-glucosaminidase (NAG) activity. In vivo and in vitro experiments showed significant increase of Michaelis constant of urinary NAG, in human and in rat, treated by amikacin. Our data indicate that the inhibition of amikacin on NAG and its isoenzymes was "apparently competitive" rather(More)
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