Jean-Louis Divoux

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We present the results of a 5-year patient follow-up after implantation of an original neuroprosthesis. The system is able to stimulate both epimysial and neural electrodes in such a way that the complete flexor-extensor chain of the lower limb can be activated without using the withdrawal reflex. We demonstrate that standing and assisted walking are(More)
This paper presents an original electronic architecture to manage epimysial and neural stimulation using the same implantable device. All the muscles needed to achieve lower limb movements such as standing and walking can thus be activated. Mainly for surgical reasons, some muscles need to be stimulated through different inputs: epimysium or motor nerve. We(More)
The new generation of implanted neuroprostheses allows muscles to be controlled with fine accuracy, high selectivity and the repeatability of the muscle’s response can be achieved. Thus, the closed loop control of such systems becomes possible. The SUAW project succeeded in the implantation of an advanced neuroprosthetic device on two patients, but the(More)
Phantom limb pain (PLP) is a chronic condition that develops in the majority of amputees. The underlying mechanisms are not completely understood, and thus, no treatment is fully effective. Based on recent studies, we hypothesize that electrical stimulation of afferent nerves might alleviate PLP by giving sensory input to the patient if nerve fibers can be(More)
This thesis investigates the analysis of brain electrical activity. An important challenge is the presence of large variability in neuroelectrical recordings, both across different subjects and within a single subject, for example across experimental trials. We propose a new method called adaptive waveform learning (AWL). It is general enough to include all(More)
This paper presents a new concept of intrafascicular multichannel electrode designed to be transversally inserted into the peripheral nerve. The ultimate goal of this electrode is to achieve high spatial fascicular and sub-fascicular selectivity, with minimal or no damage to the neural tissue. Acute in-vivo measurements on rat sciatic nerves during(More)
A wearable, 56-channel stimulator was developed and successfully tested to drive multichannel intrafascicular electrodes. It is able to safely elicit sensory afferent signals through the activation of 4 Time-4H intrafascicular electrodes. The STIMEP embeds not only the pulse generator but also a software that ensures: i) real time control by a(More)
BACKGROUND Abdominal bilateral vagal stimulation reduces food intake in animals. However, the classical square wave, mA range current generator is poorly effective to evoke action potentials on A∂ and C neurons that represent the majority of vagal neurons at the abdominal level. OBJECTIVE/HYPOTHESIS METHODS: The current thresholds for pulsons (S2 & S3)(More)
Acute vagal stimulation modifies glucose and insulin metabolism, but the effect of chronic bilateral vagal stimulation is not known. Our aim was to quantify the changes in whole-body and organ-specific insulin sensitivities 12 weeks after permanent, bilateral, vagal stimulation performed at the abdominal level in adult mini-pigs. In 15 adult mini-pigs,(More)
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