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Glycogen Synthase Kinase-3 Interacts with and Phosphorylates Estrogen Receptor α and Is Involved in the Regulation of Receptor Activity*
Like other steroid hormone receptors, estrogen receptor-α (ERα) is a substrate for protein kinases, and phosphorylation has profound effects on the function and activity of this receptor. A number ofExpand
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Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines.
Insulin and insulin analogs stimulate proliferation of human mammary epithelial cells. We identified and analyzed the signaling pathways related to cell proliferation induced by regular insulin andExpand
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Glycogen Synthase Kinase-3 Interacts with and Phosphorylates Estrogen Receptor and Is Involved in the
Like other steroid hormone receptors, estrogen receptor- (ER) is a substrate for protein kinases, and phosphorylation has profound effects on the function and activity of this receptor. A number ofExpand
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Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor.
Glycogen synthase kinase-3 (GSK-3) plays a key role in the regulation of transcription factors including steroid receptors. Having identified estrogen receptor-alpha (ERalpha) as substrate for GSK-3,Expand
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Specific involvement of glycogen synthase kinase-3 in the function and activity of sex steroid hormone receptors reveals the complexity of their regulation
Protein kinases represent key nodes for the integration of multiple intracellular signalling pathways, resulting in modulation of both ligand-dependent and ligand-independent mechanisms of sexExpand
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JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease
Background ; The gain-of-function JAK2 mutation, JAK2V617F, is the most common molecular abnormality in myeloproliferative neoplasms (MPNs) and appears in patients with polycythemia vera (PV),Expand
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Interaction between Glycogen Synthase Kinase-3 and Estrogen Receptor-alpha in ligand-dependent activation of the receptor
Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase with docking properties, regulates numerous cellular processes. Two isoforms, GSK-3alpha and GSK-3beta have been described. In vivo,Expand