Jean-Francois Dhainaut

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OBJECTIVE To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004. DESIGN Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key(More)
INTRODUCTION Protein C, because of its central role in hemostasis, plays an integral role in the host response to infection. Protein C depletion, resulting from increased consumption, degradation, and/or decreased synthesis, is characteristic of sepsis and has been shown to predict morbidity and mortality. The objective of this study was to determine(More)
Dear Editor, The steering committee (SC) of the PROWESS SHOCK study has put in place processes that should guarantee independence and transparency to resolve the controversies surrounding the investigation and use of drotr-ecogin alfa (activated), thus serving the best interests of our patients [1]. The SC anticipated that the mortality rates from sepsis(More)
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