Jean-François Tomb

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BACKGROUND Acetate is the major source of methane in nature. The majority of investigations have focused on acetotrophic methanogens for which energy-conserving electron transport is dependent on the production and consumption of H₂ as an intermediate, although the great majority of acetotrophs are unable to metabolize H₂. The presence of cytochrome c and a(More)
Sequence assembly is an essential requirement for determining the complete sequence of long DNA. However, sequence assembly programs often generate misassembled contigs by either joining diierent repeat copies, resulting in joining non contiguous DNA regions (inverted or swapped) or by including many fragments from diierent repeat copies resulting in errors(More)
Elementary flux modes (EFMs) have been claimed as one of the most promising approaches for pathway analysis. These are a set of vectors that emerge from the stoichiometric matrix of a biochemical network through the use of convex analysis. The computation of all EFMs of a given network is an NP-hard problem and existing algorithms do not scale well.(More)
Flux analysis methods lie at the core of Metabolic Engineering (ME), providing methods for phenotype simulation that allow the determination of flux distributions under different conditions. Although many constraint-based modeling software tools have been developed and published, none provides a free user-friendly application that makes available the full(More)
Elementary Flux Modes (EFMs) have been claimed as one of the most promising approaches for pathway analysis. These are a set of vectors that emerge from the stoichiometric matrix of a biochemical network through the use of convex analysis. The computation of all EFMs of a given network is an NP-hard problem and existing algorithms do not scale well.(More)
  • J W Tomb
states that an error has occurred in the account of the part which he took in the discussion on " The Toxic Effects of Arsenobenzol Treatment and their Prevention," as printed in our July issue. He is there quoted as having said " he had had one case of dermatitis, but never one of jaundice." Dr. Semon, in the course of his statement, did not say that he(More)
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