Jean François Tanti

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Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family. In vitro studies have shown that SHIP2, in response(More)
Background The anti-diabetic drug metformin has been shown to affect cancer cell metabolism [1,2] and to display anti-tumoral properties in numerous cancers [3,4], however, its role in the formation of metastases remains poorly documented. Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the(More)
To examine whether G protein were affected in the obese insulin-resistant state, the level of various G proteins (alpha i1, alpha i2, alpha i3, alpha o and alpha s) was assessed by immunodetection in lean and experimentally induced obese mice. Crude membranes were prepared from adipose tissues, muscle, liver, kidney and brain. G alpha-subunits were similar(More)
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