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Abstract The synthesis of enantiomerically pure RP-67,580, a novel nonpeptide Substance P receptor antagonist, is described as well as the resolution of intermediate perhydroisoindolone.
Abstract The synthesis of enentiomerically pure RPR 100893, a novel non peptide NK1 Substance P antagonist, is described. This compound is a representative of 7,7,4-triaryl perhydroisoindol-4-ols, a… (More)
Abstract 1,3-Dipolar cycloaddition of 3-oxidopyridinium betaine to activated olefins on solid-phase leads to resin-bound 8-azabicyclo[3.2.1]octenones which undergo further transformations such as… (More)
A simple preparation of N-substituted 3-pyrroline boromic esters from primary amines is described. The Suzuki-Miyaura coupling of these heterocycles with aryl halides proceeds in good yields.… (More)
NEW MATERIAL: A compound of formula I [R 1 is 1,2,3,6-tetrahydro-1-pyridyl, 1-piperazinyl or piperidino, all being substituted in the 4-position; R 2 is SO 2 R 4 (R 4 is alkyl or phenyl); R 3 is… (More)
PRECIS DE LA DIVULGATION: . L'invention concerne de nouvelles cephalosporines re-pondant a la formule generale: (I) dans laquelle R est un radical alcoyle, L amino-2 carboxy-2 ethyle, phenyle,… (More)