Jean François Le Bas

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BACKGROUND Recent papers suggest that two angiogenic factors (angiopoietin 2 and vascular endothelial growth factor) cooperate in tumoral angiogenesis to support the growing tumor. The purpose of the present work was to demonstrate the existence of such cooperation in a longitudinal study of a brain tumor model during tumor growth by means of(More)
PURPOSE Enhancement of the radiation dose delivered to a brain tumor can be achieved by infusing an iodinated contrast agent to the patient and irradiating with kilovoltage X-rays in computed tomography (CT) mode. Synchrotron sources, providing monochromatic tunable intense beams, are ideal for this treatment. The aim of this study is to assess in vivo the(More)
BACKGROUND Cognitive dysfunctioning (CDF) is an important issue in stroke, interfering with recovery and social dysfunctioning. We aimed to investigate the clinical and imaging correlates of CDF in patients with a first-ever subacute ischemic stroke and no dementia. METHODS We evaluated CDF 15 days after stroke in a prospective cohort of consecutive(More)
Ablative functional neurosurgery constituted during the first half of the 20th century the main treatment of advanced forms of Parkinson's disease. The surgical procedure was spectacularly efficient on tremor, but sometimes complications were not totally regressive and even more severe when surgery was bilateral, this leading to neurocognitive deficits or(More)
A 50-year-old man was referred for subacute intracranial hypertension. MRI revealed a well-circumscribed lesion in the posterior fossa that was hypointense on T1-weighted imaging and hyperintense on T2-weighted imaging (figure 1, A and E). Cerebral blood volume map and sequential postcontrast T1-weighted images showed progressive increase in the homogeneity(More)
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