Jean-François Bonneville

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BACKGROUND Carotid stenting is less invasive than endarterectomy, but it is unclear whether it is as safe in patients with symptomatic carotid-artery stenosis. METHODS We conducted a multicenter, randomized, noninferiority trial to compare stenting with endarterectomy in patients with a symptomatic carotid stenosis of at least 60%. The primary end point(More)
T1 signal hyperintensity is a common finding at magnetic resonance imaging of the sellar region. However, this signal intensity pattern has different sources, and its significance depends on the clinical context. Normal variations in sellar T1 signal hyperintensity are related to vasopressin storage in the neurohypophysis, the presence of bone marrow in(More)
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case–control study(More)
Today, MR is the only method needed for the morphological investigation of endocrine-active pituitary adenomas. In acromegaly and Cushing’s syndrome, the therapeutic attitude is directly dictated by MR data. We present the MR aspect of pituitary adenomas according to size, sex, age, endocrine activity and a few particular conditions such as hemorrhagic(More)
Responses of GH-secreting adenomas to multimodal management of acromegaly vary widely between patients. Understanding the behavioral patterns of GH-secreting adenomas by identifying factors predictive of their evolution is a research priority. The aim of this study was to clarify the relationship between the T2-weighted adenoma signal on diagnostic magnetic(More)
This paper describes the Mediating Agent, an animated pedagogical agent inserted in a computational system for distance learning, which has the goal of motivating the student to learn as well as promoting a positive mood in the student, which is more appropriate to learning. In order to accomplish its function, the agent should recognize the student’s(More)
PURPOSE To evaluate endovascular procedures in the management of acute ischemic complications and rupture of the false lumen in aortic dissections. METHODS Data on patients with aortic dissection and noncardiac acute complications (peripheral ischemia or thoracic aortic rupture) treated with endovascular techniques were collected from 10 institutions and(More)
Forty-seven extraforaminal lumbar disc herniations (EFLDH) accounting for 7% of all lumbar disc herniations encountered during the same period of time were reviewed. L3–L4 or L4–L5 disc was involved in 89% of the cases giving rise to a L3 or L4 nerve root compression. An abnormal motion of lateral bending with rotation of the trunk was found retrospectively(More)
The pattern of adenohypophysitis is that of an enlarged pituitary gland in a normal sized sellar turcica with intense enhancement after gadolinium injection. The pattern of infundibulo-neurohypophysitis is that of a diabetes insipidus, i.e. enlargement of the pituitary stalk without any storage of the antidiuretic hormone.