Jean François Abgrall

Learn More
Rearrangements involving the IGH gene have been identified in about 50% of non-Hodgkin's B-cell lymphomas (NHL) and correlated to clinical relevant subgroups. However, the detection rate varied greatly with the technique used. The incidence of IGH rearrangements was analyzed using several fluorescence in situ hybridization (FISH) techniques on metaphases(More)
The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, is associated with an increased risk of venous thromboembolism (VTE). We aimed to determine the annual incidence of VTE in first-degree relatives of patients with VTE and FVL and to identify factors in patients and the relatives that influence this incidence. In(More)
In the context of biological complex systems multi-agent simulation, we present an interaction-agentmodel for reaction-diffusion problems that enables interaction with the simulation during the execution, and we establish a mathematical validation for our model. We use two types of interaction-agents: on one hand, in a chemical reactor with no spatial(More)
We report on a new method based on speckle size analysis and devoted to particle aggregation measurements. The experimental measurements give the speckle size variation during a salt aggregation process of polystyrene microspheres. The measurements are taken at a fixed monomer concentration, varying the salt concentration. Moreover, we applied this(More)
In the context of multi-agent simulation of biological complex systems , we present a reaction-agent model for biological chemical kinetics that enables interaction with the simulation during the execution. In a chemical reactor with no spatial dimension-e.g. a cell-, a reaction-agent represents an autonomous chemical reaction between several reactants : it(More)
Acute lymphoblastic leukemia (ALL) is associated with recurrent chromosomal abnormalities. The cryptic translocation t(12;21)(p13;q22), which leads to the TEL-AML1 fusion gene, is the most common abnormality in childhood B-cell ALL. The aim of this retrospective study was to determine the incidence of TEL-AML1 fusion in childhood and adult B-cell ALL using(More)
Background. Primary bone lymphoma (PBL) is a rare entity that has only been reviewed in one prospective and small retrospective studies, from which it is difficult to establish treatment guidelines. We prospectively evaluated high-dose or conventional anthracycline-cyclophosphamide dose and radiotherapy for PBL. Patients and Methods. The GOELAMS prospective(More)
BACKGROUND Several attempts have been made to determine whether interphase fluorescence in situ hybridization (I-FISH) on bone marrow or peripheral blood specimens is a good alternative to conventional cytogenetics (CC) in calculating the residual proportion of Philadelphia (Ph) chromosome-positive cells during treatment follow-up of patients with chronic(More)