Jean Creighton

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BACKGROUND/AIMS Mutations in the cationic trypsinogen gene have been detected in patients with hereditary pancreatitis (HP). This study investigates the prevalence of the R122H, N29I, A16V and -28delTCC mutations in the common, non-hereditary forms of chronic pancreatitis and in a HP family. METHODS DNA was prepared from blood samples of 53 patients with(More)
BACKGROUND Hereditary pancreatitis has been shown to be caused by one of two mutations (R117H and N21I) of the cationic trypsinogen gene (PRSS1). Families with hereditary pancreatitis in the north of England were investigated for these mutations. The clinical features associated with each mutation were compared. METHODS In individuals from nine families(More)
I started school in a one-room school house with nine grades but just six students. I was the entire kindergarten (called ‘primary’ in Iowa). The teacher would call us one by one to sit in the chair next to her desk. In my case, it was always a pleasant interlude. There was never a sense in my mind that she wanted me to do something. She would often mention(More)
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