Jean Cohen

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Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia

Jean-Marc Aury, Olivier Jaillon, +40 authors Patrick Wincker
Nature
2006

The duplication of entire genomes has long been recognized as having great potential for evolutionary novelties, but the mechanisms underlying their resolution through gene loss are poorly… (More)

Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse.

Brigid L. M. Hogan, Gwynn Horsburgh, Jean Cohen, Colin M. Hetherington, Graham Fisher, Mary Frances Lyon
Journal of embryology and experimental morphology
1986

Small eyes (Sey) is a semidominant, homozygous lethal mutation in the mouse (Roberts, 1967). It is allelic with SeyH, a radiation-induced homozygous prenatal lethal which has been mapped on… (More)

The vacuolar proton-ATPase plays a major role in several membrane-bounded organelles in Paramecium.

Thomas Wassmer, Marine Froissard, Helmut Plattner, Roland Kissmehl, Jean Cohen
Journal of cell science
2005

The vacuolar proton-ATPase (V-ATPase) is a multisubunit enzyme complex that is able to transfer protons over membranes against an electrochemical potential under ATP hydrolysis. The enzyme consists… (More)

Fertility and ageing.

DavidT. Baird, John A. Collins, +17 authors Basil C. Tarlatzis
Human reproduction update
2005

The late 20th century trend to delay birth of the first child until the age at which female fecundity or reproductive capacity is lower has increased the incidence of age-related infertility. The… (More)

Detection of group B and C rotaviruses by polymerase chain reaction.

Vera Gouvea, James R. Allen, +7 authors E. Owen Caul
Journal of clinical microbiology
1991

We adapted the polymerase chain reaction (PCR) to detect the noncultivatable group B and C rotaviruses and introduced a simple and convenient technique to purify viral RNA from stool specimens.… (More)

Genetic approach to regulated exocytosis using functional complementation in Paramecium: identification of the ND7 gene required for membrane fusion.

Feriel Skouri, Jean Cohen
Molecular biology of the cell
1997

Paramecium is a unicellular organism that possesses a specialized pathway for regulated secretion that is amenable to genetic studies. Numerous mutations affecting the process have been isolated over… (More)

ParameciumDB: a community resource that integrates the Paramecium tetraurelia genome sequence with genetic data

Olivier Arnaiz, Scott Cain, Jean Cohen, Linda Sperling
Nucleic Acids Research
2007

ParameciumDB (http://paramecium.cgm.cnrs-gif.fr) is a new model organism database associated with the genome sequencing project of the unicellular eukaryote Paramecium tetraurelia. Built with the… (More)

Translational control of intron splicing in eukaryotes

Olivier Jaillon, Khaled Bouhouche, +16 authors E. Meyer
Nature
2008

Most eukaryotic genes are interrupted by non-coding introns that must be accurately removed from pre-messenger RNAs to produce translatable mRNAs. Splicing is guided locally by short conserved… (More)

Seventeen a-subunit isoforms of paramecium V-ATPase provide high specialization in localization and function.

Thomas Wassmer, Roland Kissmehl, Jean Cohen, Helmut Plattner
Molecular biology of the cell
2006

In the Paramecium tetraurelia genome, 17 genes encoding the 100-kDa-subunit (a-subunit) of the vacuolar-proton-ATPase were identified, representing by far the largest number of a-subunit genes… (More)

The domain architecture of large guanine nucleotide exchange factors for the small GTP-binding protein Arf

Barbara Mouratou, Valérie Biou, +6 authors Jacqueline Cherfils
BMC Genomics
2004

Small G proteins, which are essential regulators of multiple cellular functions, are activated by guanine nucleotide exchange factors (GEFs) that stimulate the exchange of the tightly bound GDP… (More)

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