Jean-Claude Pechère

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BACKGROUND Because clarithromycin provided beneficiary nonantibiotic effects in experimental studies, its efficacy was tested in patients with sepsis and ventilator-associated pneumonia (VAP). METHODS Two hundred patients with sepsis and VAP were enrolled in a double-blind, randomized, multicenter trial from June 2004 until November 2005. Clarithromycin(More)
Raymond et al. from the University of Virginia, USA published work into rotating empirical antibiotics in an intensive care unit in June 2001 [1]. This was the first time that a quarterly rotation of empirical antibiotics used for 1 year was compared with the previous year of non-protocol-driven use in critically ill patients. The research showed that(More)
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