Jean Claude Bregliano

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Several dysgenic traits may occur within the Drosophila melanogaster species as a result of crosses between different strains. Crossing two mutually interacting categories, named inducer and reactive, may lead, among other abnormalities, to a specific kind of female sterility that has proved useful for investigating the genetic factors involved in the(More)
In the I-R hybrid dysgenesis system, Drosophila melanogaster strains fall into two categories denoted inducer (I) and reactive (R). Among the reactive strains we can distinguish strains with weak, medium or strong reactivity levels. These levels are inherited in a complex way involving both chromosomal and nonchromosomal determinants, the nonchromosomal(More)
In the I-R system of hybrid dysgenesis in Drosophila melanogaster, the transposition frequency of I factor, a LINE element-like retrotransposon, is regulated by the reactivity level of the R mother. This reactivity is a cellular state maternally inherited but chromosomally determined, which has been shown to undergo heritable, cumulative and reversible(More)
In a previous paper, we reported that the reactivity level, which regulates the frequency of transposition of I factor, a LINE element-like retrotransposon, is enhanced by the same agents that induce the SOS response in Escherichia coli. In this report, we describe experimental evidence that, for identical genotypes, the reactivity levels correlate with the(More)
When Drosophila melanogaster males coming from a class of strains known as inducer are crossed with females from the complementary class (reactive), a quite specific kind of sterility is observed in the F1 female progeny (denoted SF). The inducer chromosomes differ from the reactive chromosomes by the presence of a transposable element (called the I factor)(More)
To test the DNA double-strand break (DSB) repair activities present in Drosophila early embryos, we have analyzed the circularization of a microinjected linear plasmid. In order to study repair by homologous recombination, the linear plasmid was injected with an homologous fragment encompassing the break. After extraction from embryos, repair products were(More)
We previously reported evidence that the so-called reactivity level, a peculiar cellular state of oocytes that regulates the frequency of transposition of I factor, a LINE element-like retrotransposon, might be one manifestation of a DNA repair system. In this article, we report data showing that the reactivity level is correlated with the frequency of(More)